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26 february 2020 13:02:58

 
Molecules, Vol. 25, Pages 1040: Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters (Molecules)
 


Amide functional groups are prominent in a broad range of organic compounds with diverse beneficial applications. In this work, we report the synthesis of these functional groups via an iron(iii) chloride-catalyzed direct amidation of esters. The reactions are conducted under solvent-free conditions and found to be compatible with a range of amine and ester substrates generating the desired amides in short reaction times and good to excellent yields at a catalyst loading of 15 mol%.


 
194 viewsCategory: Biochemistry, Chemistry, Molecular Biology
 
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