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RSS FeedsIJMS, Vol. 21, Pages 1594: Determinants of Resistance to Checkpoint Inhibitors (International Journal of Molecular Sciences)

 
 

26 february 2020 16:00:15

 
IJMS, Vol. 21, Pages 1594: Determinants of Resistance to Checkpoint Inhibitors (International Journal of Molecular Sciences)
 


The development of immune checkpoint inhibitors (ICIs) has drastically altered the landscape of cancer treatment. Since approval of the first ICI for the treatment of advanced melanoma in 2011, several therapeutic agents have been Food and Drug Administration (FDA)-approved for multiple cancers, and hundreds of clinical trials are currently ongoing. These antibodies disrupt T-cell inhibitory pathways established by tumor cells and thus re-activate the host’s antitumor immune response. While successful in many cancers, several types remain relatively refractory to treatment or patients develop early recurrence. Hence, there is a great need to further elucidate mechanisms of resistant disease and determine novel, effective, and tolerable combination therapies to enhance efficacy of ICIs.


 
193 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
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IJMS, Vol. 21, Pages 1595: Investigation of a Novel Salt Stress-Responsive Pathway Mediated by Arabidopsis DEAD-Box RNA Helicase Gene AtRH17 Using RNA-Seq Analysis (International Journal of Molecular Sciences)
 
 
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