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RSS FeedsIJMS, Vol. 21, Pages 2282: Disorders of Sex Development--Novel Regulators, Impacts on Fertility, and Options for Fertility Preservation (International Journal of Molecular Sciences)

 
 

26 march 2020 16:00:56

 
IJMS, Vol. 21, Pages 2282: Disorders of Sex Development--Novel Regulators, Impacts on Fertility, and Options for Fertility Preservation (International Journal of Molecular Sciences)
 


Disorders (or differences) of sex development (DSD) are a heterogeneous group of congenital conditions with variations in chromosomal, gonadal, or anatomical sex. Impaired gonadal development is central to the pathogenesis of the majority of DSDs and therefore a clear understanding of gonadal development is essential to comprehend the impacts of these disorders on the individual, including impacts on future fertility. Gonadal development was traditionally considered to involve a primary ‘male’ pathway leading to testicular development as a result of expression of a small number of key testis-determining genes. However, it is increasingly recognized that there are several gene networks involved in the development of the bipotential gonad towards either a testicular or ovarian fate. This includes genes that act antagonistically to regulate gonadal development. This review will highlight some of the novel regulators of gonadal development and how the identification of these has enhanced understanding of gonadal development and the pathogenesis of DSD. We will also describe the impact of DSDs on fertility and options for fertility preservation in this context.


 
186 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
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