Imprinted Small RNAs Unraveled: Maternal MicroRNAs Antagonize a Paternal-Genome-Driven Gene Expression Network (Molecular Cell)

Whipple et al. (2020) describe that, in neurons, a dense cluster of maternally expressed microRNAs post-transcriptionally downregulates several imprinted genes expressed from the paternal genome--an antagonistic mechanism that modulates neuronal functions and provides insights into the evolution of genomic imprinting.