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RSS FeedsFBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster (Molecular Cell)

 
 

2 april 2020 21:00:29

 
FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster (Molecular Cell)
 


Wang et al. discovered an unexpected [2Fe2S] cluster in FBXL5, which enables the F-box protein to promote iron- and oxygen-sensitive degradation of IRP2 in iron homeostasis regulation. The authors further determined the cryo-EM structure of the FBXL5-IRP2 complex and revealed the structural basis of [2Fe2S] cluster-mediated IRP2 recognition by FBXL5.


 
181 viewsCategory: Molecular Biology, Cell Biology
 
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