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2 april 2020 21:00:29

 
Lamina-Dependent Stretching and Unconventional Chromosome Compartments in Early C. elegans Embryos (Molecular Cell)
 


Sawh et al. use chromosome tracing to map whole-chromosome architecture during C. elegans embryogenesis. They show conventional A/B compartments arise at gastrulation. Prior to this developmental milestone, chromosomes adopt an extended barbell-like configuration, which requires stretching by the nuclear lamina. Unsupervised clustering further uncovers the prevalent conformations in single chromosomes.


 
167 viewsCategory: Molecular Biology, Cell Biology
 
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