Chromatin Hyperacetylation Impacts Chromosome Folding by Forming a Nuclear Subcompartment (Molecular Cell)

Rosencrance et al. find that hyperacetylated chromatin domains formed by the BRD4-NUT fusion oncoprotein interact over hundreds of megabases and even between chromosomes resulting in formation of a specific nuclear subcompartment. Subcompartment interactions are lost after small-molecule degradation of BRD4-NUT but persist when RNA polymerase II initiation is inhibited.