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RSS FeedsA checkpoint cliffhanger at the dawn of placental mammals [Protein Structure and Folding] (Journal of Biological Chemistry)

 
 

4 april 2020 03:00:17

 
A checkpoint cliffhanger at the dawn of placental mammals [Protein Structure and Folding] (Journal of Biological Chemistry)
 


The PD-1 ligands PD-L1 and PD-L2 are commonly expressed on the surface of cells, where they regulate immune system activation. However, the specific role played by each ligand has been unclear. Using site-directed mutagenesis, surface plasmon resonance, and crystallography, Philips et al. explore the distinct features of PD-L2 and identify a specific evolutionary event linked to its appearance. This work provides a deeper understanding of how the immune system adapted to mammalian placental gestation and could be an important consideration in the development of new immune checkpoint therapies.


 
16 viewsCategory: Biochemistry
 
The structural features that distinguish PD-L2 from PD-L1 emerged in placental mammals [Immunology] (Journal of Biological Chemistry)
Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply [Molecular Bases of Disease] (Journal of Biological Chemistry)
 
 
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