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RSS FeedsIJMS, Vol. 21, Pages 2532: Immunotherapy in Renal Cell Carcinoma: The Future Is Now (International Journal of Molecular Sciences)

 
 

5 april 2020 18:00:09

 
IJMS, Vol. 21, Pages 2532: Immunotherapy in Renal Cell Carcinoma: The Future Is Now (International Journal of Molecular Sciences)
 


Renal cell carcinoma is the third type of urologic cancer and has a poor prognosis with 30% of metastatic patients at diagnosis. The antiangiogenics and targeted immunotherapies led to treatment remodeling emphasizing the role of the tumour microenvironment. However, long-term responses are rare with a high rate of resistance. New strategies are emerging to improve the efficacy and the emerging drugs are under evaluation in ongoing trials. With the different treatment options, there is an urgent need to identify biomarkers in order to predict the efficacy of drugs and to better stratify patients. Owing to the limitations of programmed death-ligand 1 (PD-L1), the most studied immunohistochemistry biomarkers, and of the tumor mutational burden, the identification of more reliable markers is an unmet need. New technologies could help in this purpose.


 
179 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 21, Pages 2533: Metabolomic Studies of Lipid Storage Disorders, with Special Reference to Niemann-Pick Type C Disease: A Critical Review with Future Perspectives (International Journal of Molecular Sciences)
IJMS, Vol. 21, Pages 2530: Effect of Pharmacological Inhibition of the Catalytic Activity of Phosphatases of Regenerating Liver in Early T Cell Receptor Signaling Dynamics and IL-2 Production (International Journal of Molecular Sciences)
 
 
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