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RSS FeedsIJMS, Vol. 21, Pages 2546: Histopathologic Features of Lymphedema: A Molecular Review (International Journal of Molecular Sciences)

 
 

6 april 2020 14:01:00

 
IJMS, Vol. 21, Pages 2546: Histopathologic Features of Lymphedema: A Molecular Review (International Journal of Molecular Sciences)
 


An estimated 5 million people in the United States are affected by secondary lymphedema, with most cases attributed to malignancies or malignancy-related treatments. The pathogenesis of secondary lymphedema has historically been attributed to lymphatic injury or dysfunction; however, recent studies illustrate the complexity of lymphedema as a disease process in which many of its clinical features such as inflammation, fibrosis, adipogenesis, and recurrent infections contribute to on-going lymphatic dysfunction in a vicious cycle. Investigations into the molecular underpinning of these features further our understanding of the pathophysiology of this disease and suggests new therapeutics.


 
177 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
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