Crossover Position Drives Chromosome Remodeling for Accurate Meiotic Chromosome Segregation (Current Biology)

Altendorfer et al. show that placing a crossover (CO) at a typically CO-deprived chromosome region results in a chromosome configuration susceptible to nondisjunction. Moreover, CO suppression at chromosome ends is a conserved feature of meiosis. This study proposes that CO placement is highly regulated to ensure productive chromosome remodeling.