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RSS FeedsStochastic Model of T Cell Repolarization during Target Elimination I (Biophysical Journal)

 
 

7 april 2020 19:02:42

 
Stochastic Model of T Cell Repolarization during Target Elimination I (Biophysical Journal)
 


Cytotoxic T lymphocytes (T) and natural killer cells are the main cytotoxic killer cells of the human body to eliminate pathogen-infected or tumorigenic cells (i.e., target cells). Once a natural killer or T cell has identified a target cell, they form a tight contact zone, the immunological synapse (IS). One then observes a repolarization of the cell involving the rotation of the microtubule (MT) cytoskeleton and a movement of the MT organizing center (MTOC) to a position that is just underneath the plasma membrane at the center of the IS.


 
176 viewsCategory: Biophysics
 
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