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7 april 2020 19:02:56

 
X Caps the Phosphate for Phospho-Rab GTPase Recognition in Ciliogenesis and Parkinson`s Disease (Structure)
 


Some Rab GTPases, after activation by GDP to GTP exchange, are phosphorylated by the LRRK2 kinase implicated in Parkinson`s disease. In the current issue of Structure, Waschbüsch et al. (2020) investigate the structural basis for recognition of active phospho-Rab GTPases by the RH2 domain of the effector protein RILPL2.


 
198 viewsCategory: Biochemistry
 
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