Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila (Cell Metabolism)

van Dam et al. disentangle the physiological effects of high-sugar feeding on survival using adult Drosophila. They uncouple diet-induced obesity and insulin resistance from shortened lifespan by rescuing sugar-induced water imbalance. Dietary sugar is linked to kidney dysfunction and dysregulation of purine catabolism in both flies and humans, emphasizing this pathway as a promising target for potential therapeutic interventions.