Integrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism (Cell Metabolism)

Here, Li et al. develop a systematic approach that integrates mouse liver co-expression networks together with human lipid GWAS datasets to identify lipid metabolism genes. Using this approach, they pinpoint Sestrin1 as a gene associated with cholesterol levels in humans and demonstrate that Sestrin1 protein can regulate cholesterol biosynthesis.