MyJournals Home  

RSS FeedsSMAD7 enhances adult {beta}-cell proliferation without significantly affecting {beta}-cell function in mice [Metabolism] (Journal of Biological Chemistry)

 
 

10 april 2020 11:02:31

 
SMAD7 enhances adult {beta}-cell proliferation without significantly affecting {beta}-cell function in mice [Metabolism] (Journal of Biological Chemistry)
 


The interplay between the transforming growth factor ? (TGF-?) signaling proteins, SMAD family member 2 (SMAD2) and 3 (SMAD3), and the TGF-?-inhibiting SMAD, SMAD7, seems to play a vital role in proper pancreatic endocrine development and also in normal ?-cell function in adult pancreatic islets. Here, we generated conditional SMAD7 knockout mice by crossing insulin1Cre mice with SMAD7fx/fx mice. We also created a ? cell-specific SMAD7-overexpressing mouse line by crossing insulin1Dre mice with HPRT-SMAD7/RosaGFP mice. We analyzed ?-cell function in adult islets when SMAD7 was either absent or overexpressed in ? cells. Loss of SMAD7 in ? cells inhibited proliferation, and SMAD7 overexpression enhanced cell proliferation. However, alterations in basic glucose homeostasis were not detectable following either SMAD7 deletion or overexpression in ? cells. Our results show that both the absence and overexpression of SMAD7 affect TGF-? signaling and modulates ?-cell proliferation but does not appear to alter ?-cell function. Reversible SMAD7 overexpression may represent an attractive therapeutic option to enhance ?-cell proliferation without negative effects on ?-cell function.


 
23 viewsCategory: Biochemistry
 
Heparin inhibits proinflammatory and promotes anti-inflammatory macrophage polarization under hyperglycemic stress [Immunology] (Journal of Biological Chemistry)
An RNA aptamer with potent affinity for a toxic dimer of amyloid {beta}42 has potential utility for histochemical studies of Alzheimer`s disease [Molecular Bases of Disease] (Journal of Biological Chemistry)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Biochemistry


Copyright © 2008 - 2020 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Nachrichten