Heme oxygenase-1 deficiency presenting with interstitial lung disease and hemophagocytic flares (Pediatric Rheumatology)

Heme oxygenase-1 (HMOX1) catalyzes the metabolism of heme into carbon monoxide, ferrous iron, and biliverdin. Through biliverdin reductase, biliverdin becomes bilirubin. HMOX1-deficiency is a rare autosomal reces...