The functional and structural characteristics of civil engineering works, in particular bridges, influence the performance of transport infrastructure. Remote sensing technology and other advanced technologies could help bridge managers review structural conditions and deteriorations through bridge inspection. This paper proposes an artificial intelligence-based methodology to solve the condition assessment of regional bridges and optimize their maintenance schemes. It includes data integration, condition assessment, and maintenance optimization. Data from bridge inspection reports is the main source of this data-driven approach, which could provide a substantial amount og condition-related information to reveal the time-variant bridge condition deterioration and effect of maintenance behaviors. The regional bridge condition deterioration model is established by neural networks, and the impact of the maintenance scheme on the future condition of bridges is quantified. Given the need to manage limited resources and ensure safety and functionality, adequate maintenance schemes for regional bridges are optimized with genetic algorithms. The proposed data-driven methodology is applied to real regional highway bridges. The regional inspection information is obtained with the help of emerging technologies. The established structural deterioration models achieve up to 85% prediction accuracy. The obtained optimal maintenance schemes could be chosen according to actual structural conditions, maintenance requirements, and total budget. Data-driven decision support can substantially aid in smart and efficient maintenance planning of road bridges.