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RSS FeedsIJERPH, Vol. 18, Pages 9730: Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction (International Journal of Environmental Research and Public Health)

 
 

15 september 2021 15:27:47

 
IJERPH, Vol. 18, Pages 9730: Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction (International Journal of Environmental Research and Public Health)
 


Skeletal muscle mass reduction has been implicated in insulin resistance (IR) that promotes cardiometabolic diseases. We have previously reported that arsenic exposure increases IR concomitantly with the reduction of skeletal muscle mass among individuals exposed to arsenic. The arsenic methylation capacity is linked to the susceptibility to some arsenic exposure-related diseases. However, it remains unknown whether the arsenic methylation capacity affects the arsenic-induced reduction of muscle mass and elevation of IR. Therefore, this study examined the associations between the arsenic methylation status and skeletal muscle mass measures with regard to IR by recruiting 437 participants from low- and high-arsenic exposure areas in Bangladesh. The subjects` skeletal muscle mass was estimated by their lean body mass (LBM) and serum creatinine levels. Subjects` drinking water arsenic concentrations were positively associated with total urinary arsenic concentrations and the percentages of MMA, as well as inversely associated with the percentages of DMA and the secondary methylation index (SMI). Subjects` LBM and serum creatinine levels were positively associated with the percentage of DMA and SMI, as well as inversely associated with the percentage of MMA. HOMA-IR showed an inverse association with SMI, with a confounding effect of sex. Our results suggest that reduced secondary methylation capacity is involved in the arsenic-induced skeletal muscle loss that may be implicated in arsenic-induced IR and cardiometabolic diseases.


 
175 viewsCategory: Medicine, Pathology, Toxicology
 
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IJERPH, Vol. 18, Pages 9732: Ecological Study of Variability in the Relationship between Liver Cancer Mortality and Racial Residential Segregation (International Journal of Environmental Research and Public Health)
 
 
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