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RSS FeedsMolecules, Vol. 26, Pages 5609: Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy (Molecules)

 
 

16 september 2021 08:28:46

 
Molecules, Vol. 26, Pages 5609: Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy (Molecules)
 


The selective disruption of nutritional supplements and the metabolic routes of cancer cells offer a promising opportunity for more efficient cancer therapeutics. Herein, a biomimetic cascade polymer nanoreactor (GOx/CAT-NC) was fabricated by encapsulating glucose oxidase (GOx) and catalase (CAT) in a porphyrin polymer nanocapsule for combined starvation and photodynamic anticancer therapy. Internalized by cancer cells, the GOx/CAT-NCs facilitate microenvironmental oxidation by catalyzing endogenous H2O2 to form O2, thereby accelerating intracellular glucose catabolism and enhancing cytotoxic singlet oxygen (1O2) production with infrared irradiation. The GOx/CAT-NCs have demonstrated synergistic advantages in long-term starvation therapy and powerful photodynamic therapy (PDT) in cancer treatment, which inhibits tumor cells at more than twice the rate of starvation therapy alone. The biomimetic polymer nanoreactor will further contribute to the advancement of complementary modes of spatiotemporal control of cancer therapy.


 
190 viewsCategory: Biochemistry, Chemistry, Molecular Biology
 
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Molecules, Vol. 26, Pages 5610: Adulteration of Essential Oils: A Multitask Issue for Quality Control. Three Case Studies: Lavandula angustifolia Mill., Citrus limon (L.) Osbeck and Melaleuca alternifolia (Maiden & Betche) Cheel (Molecules)
 
 
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