The Haiyang 2B (HY-2B) satellite requires precise orbit determination (POD) products for geodetic remote sensing techniques. An improved set of reduced-dynamic (RD) orbit solutions was generated from the onboard Global Positioning System (GPS) measurements over a 14-month period using refined strategies and processing techniques. The key POD strategies include a refined empirical acceleration model, in-flight calibration of the GPS antenna, and the resolution of single-receiver carrier-phase ambiguities. In this study, the potential periodicity of empirical acceleration in the HY-2B POD was identified by spectral analysis. In the along-track direction, a noticeable signal with four cycles per revolution (CPR) was significant. A mixed spectrum was observed for the cross-track direction. To better understand the real in-flight environment, a refined empirical acceleration model was used to cope with the time variability of empirical accelerations in HY-2B POD. Three POD strategies were used for the reprocessing for superior orbit quality. Validation using over one year of satellite laser ranging (SLR) measurements demonstrated a 5.2% improvement in the orbit solution of the refined model. Reliable correction for the GPS antenna phase center was obtained from an over-420-day dataset, and a trend in radial offset change was observed. After application of the in-flight calibration of the GPS antenna, a 26% reduction in the RMS SLR residuals was achieved for the RD orbit solution, and the carrier phase residuals were clearly reduced. The integer ambiguity resolution of HY-2B led to strong geometric constraints for the estimated parameters, and a 15% improvement in the SLR residuals could be inferred compared with the float solution.