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RSS FeedsIJMS, Vol. 22, Pages 10033: Impact of Stilbenes as Epigenetic Modulators of Breast Cancer Risk and Associated Biomarkers (International Journal of Molecular Sciences)

 
 

17 september 2021 10:58:05

 
IJMS, Vol. 22, Pages 10033: Impact of Stilbenes as Epigenetic Modulators of Breast Cancer Risk and Associated Biomarkers (International Journal of Molecular Sciences)
 


With the recent advancement of genetic screening for testing susceptibility to mammary oncogenesis in women, the relevance of the geneāˆ`environment interaction has become progressively apparent in the context of aberrant gene expressions. Fetal exposure to external stressors, hormones, and nutrients, along with the inherited genome, impact its traits, including cancer susceptibility. Currently, there is increasing interest in the role of epigenetic biomarkers such as genomic methylation signatures, plasma microRNAs, and alterations in cell-signaling pathways in the diagnosis and primary prevention of breast cancer, as well as its prognosis. Polyphenols like natural stilbenes have been shown to be effective in chemoprevention by exerting cytotoxic effects that can stall cell proliferation. Besides possessing antioxidant properties against the DNA-damaging effects of reactive oxygen species, stilbenes have also been observed to modulate cell-signaling pathways. With the increasing trend of early-life screening for hereditary breast cancer risks, the potency of different phytochemicals in harnessing the epigenetic biomarkers of breast cancer risk demand more investigation. This review will explore means of exploiting the abilities of stilbenes in altering the underlying factors that influence breast cancer risk, as well as the appearance of associated biomarkers.


 
206 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 22, Pages 10032: Gephyrin-Lacking PV Synapses on Neocortical Pyramidal Neurons (International Journal of Molecular Sciences)
IJMS, Vol. 22, Pages 10034: Extracellular Calcium Ion Concentration Regulates Chondrocyte Elastic Modulus and Adhesion Behavior (International Journal of Molecular Sciences)
 
 
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