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RSS FeedsIJMS, Vol. 22, Pages 11263: Cyclic FEE Peptide Improves Human Sperm Movement Parameters without Modification of Their Energy Metabolism (International Journal of Molecular Sciences)

 
 

19 october 2021 11:59:03

 
IJMS, Vol. 22, Pages 11263: Cyclic FEE Peptide Improves Human Sperm Movement Parameters without Modification of Their Energy Metabolism (International Journal of Molecular Sciences)
 


Cyclic fertilin peptide (cFEE: phenylalanine, glutamic acid; glutamic acid) improves gamete interaction in humans. We investigate whether it could be via improvement of sperm movement parameters and their mitochondrial ATP production. Sperm movement parameters were studied using computer-assisted sperm analysis (CASA) in sperm samples from 38 patients with normal sperm in medium supplemented with cyclic fertilin against a control group. Sperm mitochondrial functions were studied using donor`s sperm, incubated or not with cFEE. It was evaluated by the measurement of their ATP production using bioluminescence, their respiration by high resolution oxygraphy, and of mitochondrial membrane potential (MMP) using potentiometric dyes and flow cytometry. cFEE significantly improved sperm movement parameters and percentage of hyperactivated sperm. Impact of inhibitors showed OXPHOS as the predominant energy source for sperm movement. However, cFEE had no significant impact on any of the analyzed mitochondrial bioenergetic parameters, suggesting that it could act via a more efficient use of its energy resources.


 
155 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 22, Pages 11262: Effect of Exogenous Melatonin on the Development of Mice Ovarian Follicles and Follicular Angiogenesis (International Journal of Molecular Sciences)
IJMS, Vol. 22, Pages 11264: Diverse Mechanisms of Antimicrobial Activities of Lactoferrins, Lactoferricins, and Other Lactoferrin-Derived Peptides (International Journal of Molecular Sciences)
 
 
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