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RSS FeedsIJMS, Vol. 22, Pages 11371: NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling and Beyond (International Journal of Molecular Sciences)

 
 

21 october 2021 13:59:54

 
IJMS, Vol. 22, Pages 11371: NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling and Beyond (International Journal of Molecular Sciences)
 


The mechanisms committed in the activation and response of vascular and inflammatory immune cells play a major role in tissue remodeling in cardiovascular diseases (CVDs) such as atherosclerosis, pulmonary arterial hypertension, and abdominal aortic aneurysm. Cardiovascular remodeling entails interrelated cellular processes (proliferation, survival/apoptosis, inflammation, extracellular matrix (ECM) synthesis/degradation, redox homeostasis, etc.) coordinately regulated by a reduced number of transcription factors. Nuclear receptors of the subfamily 4 group A (NR4A) have recently emerged as key master genes in multiple cellular processes and vital functions of different organs, and have been involved in a variety of high-incidence human pathologies including atherosclerosis and other CVDs. This paper reviews the major findings involving NR4A3 (Neuron-derived Orphan Receptor 1, NOR-1) in the cardiovascular remodeling operating in these diseases.


 
159 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 22, Pages 11368: PRC1 Stabilizes Cardiac Contraction by Regulating Cardiac Sarcomere Assembly and Cardiac Conduction System Construction (International Journal of Molecular Sciences)
IJMS, Vol. 22, Pages 11373: PVDF and P(VDF-TrFE) Electrospun Scaffolds for Nerve Graft Engineering: A Comparative Study on Piezoelectric and Structural Properties, and In Vitro Biocompatibility (International Journal of Molecular Sciences)
 
 
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