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RSS FeedsIJMS, Vol. 22, Pages 13073: Circulating Tumor Cells in Hepatocellular Carcinoma: A Comprehensive Review and Critical Appraisal (International Journal of Molecular Sciences)

 
 

3 december 2021 22:01:44

 
IJMS, Vol. 22, Pages 13073: Circulating Tumor Cells in Hepatocellular Carcinoma: A Comprehensive Review and Critical Appraisal (International Journal of Molecular Sciences)
 


Hepatocellular carcinoma (HCC) is the fifth most common neoplasm and a major cause of cancer-related death worldwide. There is no ideal biomarker allowing early diagnosis of HCC and tumor surveillance in patients receiving therapy. Liquid biopsy, and particularly circulating tumor cells (CTCs), have emerged as a useful tool for diagnosis and monitoring therapeutic responses in different tumors. In the present manuscript, we evaluate the current evidence supporting the quantitative and qualitative assessment of CTCs as potential biomarkers of HCC, as well as technical aspects related to isolation, identification, and classification of CTCs. Although the dynamic assessment of CTCs in patients with HCC may aid the decision-making process, there are still many uncertainties and technical caveats to be solved before this methodology has a true impact on clinical practice guidelines. More studies are needed to identify the optimal combination of surface markers, to increase the efficiency of ex-vivo expansion of CTCs, or even to target CTCs as a potential therapeutic strategy to prevent HCC recurrence after surgery or to hamper tumor progression and extrahepatic spreading.


 
74 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 22, Pages 13075: Exploration of the Effect on Genome-Wide DNA Methylation by miR-143 Knock-Out in Mice Liver (International Journal of Molecular Sciences)
IJMS, Vol. 22, Pages 13072: The Secretome of Human Neonatal Mesenchymal Stem Cells Modulates Doxorubicin-Induced Cytotoxicity: Impact in Non-Tumor Cells (International Journal of Molecular Sciences)
 
 
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