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RSS FeedsEntropy, Vol. 23, Pages 1633: Network Dynamics in Elemental Assimilation and Metabolism (Entropy)

 
 

4 december 2021 13:20:30

 
Entropy, Vol. 23, Pages 1633: Network Dynamics in Elemental Assimilation and Metabolism (Entropy)
 


Metabolism and physiology frequently follow non-linear rhythmic patterns which are reflected in concepts of homeostasis and circadian rhythms, yet few biomarkers are studied as dynamical systems. For instance, healthy human development depends on the assimilation and metabolism of essential elements, often accompanied by exposures to non-essential elements which may be toxic. In this study, we applied laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) to reconstruct longitudinal exposure profiles of essential and non-essential elements throughout prenatal and early post-natal development. We applied cross-recurrence quantification analysis (CRQA) to characterize dynamics involved in elemental integration, and to construct a graph-theory based analysis of elemental metabolism. Our findings show how exposure to lead, a well-characterized toxicant, perturbs the metabolism of essential elements. In particular, our findings indicate that high levels of lead exposure dysregulate global aspects of metabolic network connectivity. For example, the magnitude of each element’s degree was increased in children exposed to high lead levels. Similarly, high lead exposure yielded discrete effects on specific essential elements, particularly zinc and magnesium, which showed reduced network metrics compared to other elements. In sum, this approach presents a new, systems-based perspective on the dynamics involved in elemental metabolism during critical periods of human development.


 
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Entropy, Vol. 23, Pages 1632: Effect of Ti on the Structure and Mechanical Properties of TixZr2.5-xTa Alloys (Entropy)
Entropy, Vol. 23, Pages 1634: Stochastic Collisional Quantum Thermometry (Entropy)
 
 
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