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RSS FeedsIJERPH, Vol. 19, Pages 1228: Chemical-Mediated Microbial Interactions Can Reduce the Effectiveness of Time-Series-Based Inference of Ecological Interaction Networks (International Journal of Environmental Research and Public Health)

 
 

22 january 2022 11:47:23

 
IJERPH, Vol. 19, Pages 1228: Chemical-Mediated Microbial Interactions Can Reduce the Effectiveness of Time-Series-Based Inference of Ecological Interaction Networks (International Journal of Environmental Research and Public Health)
 


Network-based assessments are important for disentangling complex microbial and microbial–host interactions and can provide the basis for microbial engineering. There is a growing recognition that chemical-mediated interactions are important for the coexistence of microbial species. However, so far, the methods used to infer microbial interactions have been validated with models assuming direct species-species interactions, such as generalized Lotka–Volterra models. Therefore, it is unclear how effective existing approaches are in detecting chemical-mediated interactions. In this paper, we used time series of simulated microbial dynamics to benchmark five major/state-of-the-art methods. We found that only two methods (CCM and LIMITS) were capable of detecting interactions. While LIMITS performed better than CCM, it was less robust to the presence of chemical-mediated interactions, and the presence of trophic competition was essential for the interactions to be detectable. We show that the existence of chemical-mediated interactions among microbial species poses a new challenge to overcome for the development of a network-based understanding of microbiomes and their interactions with hosts and the environment.


 
71 viewsCategory: Medicine, Pathology, Toxicology
 
IJERPH, Vol. 19, Pages 1234: Theoretical Background of Occupational-Exposure Models—Report of an Expert Workshop of the ISES Europe Working Group “Exposure Models” (International Journal of Environmental Research and Public Health)
IJERPH, Vol. 19, Pages 1236: Influence of Chewing Ability on Elderly Adults’ Cognitive Functioning: The Mediating Effects of the Ability to Perform Daily Life Activities and Nutritional Status (International Journal of Environmental Research and Public Health)
 
 
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