The increased focus on energy efficiency, both at the national and international levels, has fostered the diffusion and development of specific energy consumption benchmarks for most relevant economic sectors. In this context, energy-intensive facilities, such as hospitals and health structures, represent a unique case. Indeed, despite the high energy consumption of these structures, scientific literature lacks the presence of adequate energy performance benchmarks, especially in regard to the European context. Thus, this study aimed at defining energy benchmark indicators for the Italian private healthcare sector using data collected from the Italian mandatory energy audits according to Art.8 EU Directive 27/2012. The benchmark indicators’ definition was made using a methodology proposed by the Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA). This methodology provided the calculation of specific energy performance indicators (EnPIs) by considering the global energy consumption of the different sites and the sector’s relevant variables. The results obtained were compared with those obtained from a consolidated but more complex methodology: the one envisaged by the Environmental Protection Agency. The results obtained allowed us to validate the reliability of the proposed methodology, as well as the validity and future usability of the calculated indicators. Relying on a significant database containing actual data from recent energy audits, this study was thus able to provide an up-to-date and reliable benchmark for the private healthcare sector.