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RSS FeedsIJMS, Vol. 23, Pages 1311: Recent Development in NKT-Based Immunotherapy of Glioblastoma: From Bench to Bedside (International Journal of Molecular Sciences)

 
 

24 january 2022 16:47:33

 
IJMS, Vol. 23, Pages 1311: Recent Development in NKT-Based Immunotherapy of Glioblastoma: From Bench to Bedside (International Journal of Molecular Sciences)
 


Glioblastoma multiforme (GBM) is an aggressive and dismal disease with a median overall survival of around 15 months and a 5-year survival rate of 7.2%. Owing to genetic mutations, drug resistance, disruption to the blood–brain barrier (BBB)/blood–brain tumor barrier (BBTB), and the complexity of the immunosuppressive environment, the therapeutic approaches to GBM represent still major challenges. Conventional therapies, including surgery, radiotherapy, and standard chemotherapy with temozolomide, have not resulted in satisfactory improvements in the overall survival of GBM patients. Among cancer immunotherapeutic approaches, we propose that adjuvant NKT immunotherapy with invariant NKT (iNKT) and cytokine-induced killer (CIK) cells may improve the clinical scenario of this devastating disease. Considering this, herein, we discuss the current strategies of NKT therapy for GBM based primarily on in vitro/in vivo experiments, clinical trials, and the combinatorial approaches with future therapeutic potential.


 
84 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 23, Pages 1307: Native Liquid Chromatography and Mass Spectrometry to Structurally and Functionally Characterize Endo-xylanase Proteoforms (International Journal of Molecular Sciences)
IJMS, Vol. 23, Pages 1309: Identification of New KRAS G12D Inhibitors through Computer-Aided Drug Discovery Methods (International Journal of Molecular Sciences)
 
 
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