Based on the field test of a 600 MW supercritical circulating-fluidized bed boiler, this paper optimizes the secondary air pipe layout scheme of a 660 MW ultra-supercritical circulating fluidized bed boiler with a similar furnace structure and carried out a numerical simulation on its air distribution uniformity. The secondary air box of the 660 MW ultra-supercritical circulating-fluidized bed boiler adopts a variable section design, and the secondary air branch pipe adopts a separate air inlet mode. The experimental results showed that the oxygen concentration was uniform near the rear wall, but all exhibited a “decrease–increase–decrease” profile along the horizontal line, which indicated that the trajectory of the secondary air jet was first in the shape of bending downward and then upward. To achieve a more uniform secondary air distribution for supercritical CFB boilers, further optimization of the layout of the bellows and branch pipes should be considered. Numerical results showed that the deviation rate of the internal and lower secondary air reached 17%, and there was optimization space for the secondary air branch pipe layout of the boiler. Its uniformity can be increased by adding valves and other measures. The velocity deviation of the secondary air of the 660 MW ultra-supercritical circulating-fluidized bed boiler can be within 3% by means of separate air supply and pipe diameter change, and better uniform air supply can be achieved to reduce the speed deviation by adding valves and adjusting the combustion.