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RSS FeedsIJMS, Vol. 23, Pages 5730: Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development (International Journal of Molecular Sciences)

 
 

20 may 2022 13:28:47

 
IJMS, Vol. 23, Pages 5730: Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development (International Journal of Molecular Sciences)
 


Lysyl oxidase-like 2 (LOXL2) and 3 (LOXL3) are members of the lysyl oxidase family of enzymes involved in the maturation of the extracellular matrix. Both enzymes share a highly conserved catalytic domain, but it is unclear whether they perform redundant functions in vivo. In this study, we show that mice lacking Loxl3 exhibit perinatal lethality and abnormal skeletal development. Additionally, analysis of the genotype of embryos carrying double knockout of Loxl2 and Loxl3 genes suggests that both enzymes have overlapping functions during mouse development. Furthermore, we also show that ubiquitous expression of Loxl2 suppresses the lethality associated with Loxl3 knockout mice.


 
115 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 23, Pages 5717: A Single Injection of NTG-101 Reduces the Expression of Pain-Related Neurotrophins in a Canine Model of Degenerative Disc Disease (International Journal of Molecular Sciences)
IJMS, Vol. 23, Pages 5729: Recent Insight into the Genetic Basis, Clinical Features, and Diagnostic Methods for Neuronal Ceroid Lipofuscinosis (International Journal of Molecular Sciences)
 
 
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