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20 may 2022 13:50:44

 
Molecules, Vol. 27, Pages 3293: N-Dealkylation of Amines (Molecules)
 


N-dealkylation, the removal of an N-alkyl group from an amine, is an important chemical transformation which provides routes for the synthesis of a wide range of pharmaceuticals, agrochemicals, bulk and fine chemicals. N-dealkylation of amines is also an important in vivo metabolic pathway in the metabolism of xenobiotics. Identification and synthesis of drug metabolites such as N-dealkylated metabolites are necessary throughout all phases of drug development studies. In this review, different approaches for the N-dealkylation of amines including chemical, catalytic, electrochemical, photochemical and enzymatic methods will be discussed.


 
99 viewsCategory: Biochemistry, Chemistry, Molecular Biology
 
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