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RSS FeedsIJMS, Vol. 23, Pages 8726: Microsatellite Instability: From the Implementation of the Detection to a Prognostic and Predictive Role in Cancers (International Journal of Molecular Sciences)

 
 

5 august 2022 12:34:26

 
IJMS, Vol. 23, Pages 8726: Microsatellite Instability: From the Implementation of the Detection to a Prognostic and Predictive Role in Cancers (International Journal of Molecular Sciences)
 


Microsatellite instability (MSI) has been identified in several tumors arising from either germline or somatic aberration. The presence of MSI in cancer predicts the sensitivity to immune checkpoint inhibitors (ICIs), particularly PD1/PD-L1 inhibitors. To date, the predictive role of MSI is currently used in the selection of colorectal cancer patients for immunotherapy; moreover, the expansion of clinical trials into other cancer types may elucidate the predictive value of MSI for non-colorectal tumors. In clinical practice, several assays are used for MSI testing, including immunohistochemistry (IHC), polymerase chain reaction (PCR) and next-generation sequencing (NGS). In this review, we provide an overview of MSI in various cancer types, highlighting its potential predictive/prognostic role and the clinical trials performed. Finally, we focus on the comparison data between the different assays used to detect MSI in clinical practice.


 
111 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 23, Pages 8723: Graphene Oxide Loaded on TiO2-Nanotube-Modified Ti Regulates the Behavior of Human Gingival Fibroblasts (International Journal of Molecular Sciences)
IJMS, Vol. 23, Pages 8724: Expression Profiling and MicroRNA Regulatory Networks of Homeobox Family Genes in Sugarcane Saccharum spontaneum L. (International Journal of Molecular Sciences)
 
 
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