The complex temperature and pressure conditions of deepwater wells have a serious impact on cementing quality. Therefore, the integrity of the cement seal becomes a critical factor that can restrict the safety of the wellbore, especially for wells ranging from the conventional deep water to deep water with more prominent deep stratum problems. The operating conditions of deep wells in deep water (referred as the dual-deep well) are complex and harsh. For the conventional evaluation device, it is difficult to accurately simulate the alternating HTHP conditions and to clarify the location and situation of the cement sheath leakage, which directly leads to the deviation of the evaluation results from the engineering reality. To solve this defect, based on the condition and structure characteristics of dual-deep wells, a device and method for casing/cement sheath/formation seal integrity evaluation for dual-deep wells at HTHP has been developed and established. Combined with the analysis of microstructure and micromorphology, the sealing ability and integrity of different cement slurry systems were evaluated. Through this study, a set of cement slurry systems suitable for dual-deep wells is selected that can satisfy the requirements of dual-deep wells with excellent isolation ability and seal integrity under temperature and stress changes. The research results provide a reference for deepwater wells’ wellbore integrity evaluation and research.