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RSS FeedsIJMS, Vol. 23, Pages 8930: Protease Profile of Tumor-Associated Mast Cells in Melanoma (International Journal of Molecular Sciences)

 
 

11 august 2022 09:04:36

 
IJMS, Vol. 23, Pages 8930: Protease Profile of Tumor-Associated Mast Cells in Melanoma (International Journal of Molecular Sciences)
 


Mast cells (MCs) produce a variety of mediators, including proteases—tryptase, chymase, and carboxypeptidases—which are important for the immune response. However, a detailed assessment of the mechanisms of biogenesis and excretion of proteases in melanoma has yet to be carried out. In this study, we present data on phenotype and secretory pathways of proteases in MCs in the course of melanoma. The development of melanoma was found to be accompanied by the appearance in the tumor-associated MC population of several pools with a predominant content of one or two specific proteases with a low content or complete absence of others. Elucidation of the molecular and morphological features of the expression of MC proteases in melanoma allows us a fresh perspective of the pathogenesis of the disease, and can be used to clarify MCs classification, the disease prognosis, and evaluate the effectiveness of ongoing antitumor therapy.


 
108 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 23, Pages 8929: Matrix Metalloproteinases in Dental and Periodontal Tissues and Their Current Inhibitors: Developmental, Degradational and Pathological Aspects (International Journal of Molecular Sciences)
IJMS, Vol. 23, Pages 8932: A Novel Homozygous Variant in DYSF Gene Is Associated with Autosomal Recessive Limb Girdle Muscular Dystrophy R2/2B (International Journal of Molecular Sciences)
 
 
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