In this work, we develop a hybrid battery thermal management (BTM) system for a 7 × 7 large battery module by coupling an epoxy resin (ER)-enhanced phase change material (PCM) module with internal liquid cooling (LC) tubes. The supporting material of ER greatly enhances the thermal stability and prevents PCM leakage under high-temperature environments. In addition, the other two components of paraffin and expanded graphite contribute a large latent heat of 189 J g−1 and a high thermal conductivity of 2.2 W m−1 K−1 to the PCM module, respectively. The LC tubes can dissipate extra heat under severe operating conditions, demonstrating effective secondary heat dissipation and avoiding heat storage saturation of the module. Consequently, during the charge-discharge tests under a 40 °C ambient temperature, the temperature of the PCM-LC battery module could be maintained below 40.48, 43.56, 45.38 and 47.61 °C with the inlet water temperature of 20, 25, 30 and 35 °C, respectively. During the continuous charge-discharge cycles, the temperature could be maintained below ~48 °C. We believe that this work contributes a guidance for designing PCM-LC-based BTM systems with high stability and reliability towards large-scale battery modules.