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RSS FeedsIJMS, Vol. 23, Pages 9084: Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans (International Journal of Molecular Sciences)

 
 

13 august 2022 12:59:08

 
IJMS, Vol. 23, Pages 9084: Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans (International Journal of Molecular Sciences)
 


Due to its preferred habitats in the environment, the free-living nematode Caenorhabditis elegans has become a realistic target organism for pollutants, including manufactured nanoparticles. In the laboratory, the invertebrate animal model represents a cost-effective tool to investigate the molecular mechanisms of the biological response to nanomaterials. With an estimated number of 22,000 coding genes and short life span of 2–3 weeks, the small worm is a giant when it comes to characterization of molecular pathways, long-term low dose pollutant effects and vulnerable age-groups. Here, we review (i) flows of manufactured nanomaterials and exposition of C. elegans in the environment, (ii) the track record of C. elegans in biomedical research, and (iii) its potential to contribute to the investigation of the exposome and bridge nanotoxicology between higher organisms, including humans. The role of C. elegans in the one health concept is taken one step further by proposing methods to sample wild nematodes and their molecular characterization by single worm proteomics.


 
136 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
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IJMS, Vol. 23, Pages 9083: Properties of New Composite Materials Based on Hydroxyapatite Ceramic and Cross-Linked Gelatin for Biomedical Applications (International Journal of Molecular Sciences)
 
 
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