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RSS FeedsIJMS, Vol. 23, Pages 14920: Treatment with EV-miRNAs Alleviates Obesity-Associated Metabolic Dysfunction in Mice (International Journal of Molecular Sciences)

 
 

29 november 2022 08:26:26

 
IJMS, Vol. 23, Pages 14920: Treatment with EV-miRNAs Alleviates Obesity-Associated Metabolic Dysfunction in Mice (International Journal of Molecular Sciences)
 


Most cells release extracellular vesicles (EVs) that can be detected circulating in blood. We and others have shown that the microRNA contents of these vesicles induce transcriptomic changes in acceptor cells, contributing to the adjustment of metabolic homeostasis in response to environmental demands. Here, we explore the potential for modulating obesity- and exercise-derived EV-microRNAs to treat the metabolic dysfunction associated with obesity in mice. Treatment with EV-miRNAs alleviated glucose intolerance and insulin resistance in obese mice to an extent similar to that of high-intensity interval training, although only exercise improved cardiorespiratory fitness and decreased body weight. Mechanistically, EV-miRNAs decreased fatty acid and cholesterol biosynthesis pathways in the liver, reducing hepatic steatosis and increasing insulin sensitivity, resulting in decreased glycemia and triglyceridemia. Our data suggest that manipulation of EV-miRNAs may be a viable strategy to alleviate metabolic dysfunction in obese and diabetic patients who are unable to exercise, although actual physical activity is needed to improve cardiorespiratory fitness.


 
84 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 23, Pages 14919: From Nucleus to Organs: Insights of Aryl Hydrocarbon Receptor Molecular Mechanisms (International Journal of Molecular Sciences)
IJMS, Vol. 23, Pages 14921: Properties and Potential Antiproliferative Activity of Thrombin-Binding Aptamer (TBA) Derivatives with One or Two Additional G-Tetrads (International Journal of Molecular Sciences)
 
 
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