MyJournals Home  

RSS FeedsEntropy, Vol. 25, Pages 235: Emergent Criticality in Coupled Boolean Networks (Entropy)


27 january 2023 16:18:41

Entropy, Vol. 25, Pages 235: Emergent Criticality in Coupled Boolean Networks (Entropy)

Early embryonic development involves forming all specialized cells from a fluid-like mass of identical stem cells. The differentiation process consists of a series of symmetry-breaking events, starting from a high-symmetry state (stem cells) to a low-symmetry state (specialized cells). This scenario closely resembles phase transitions in statistical mechanics. To theoretically study this hypothesis, we model embryonic stem cell (ESC) populations through a coupled Boolean network (BN) model. The interaction is applied using a multilayer Ising model that considers paracrine and autocrine signaling, along with external interventions. It is demonstrated that cell-to-cell variability can be interpreted as a mixture of steady-state probability distributions. Simulations have revealed that such models can undergo a series of first- and second-order phase transitions as a function of the system parameters that describe gene expression noise and interaction strengths. These phase transitions result in spontaneous symmetry-breaking events that generate new types of cells characterized by various steady-state distributions. Coupled BNs have also been shown to self-organize in states that allow spontaneous cell differentiation.

56 viewsCategory: Informatics, Physics
Entropy, Vol. 25, Pages 234: Coarse-Grained Effective Hamiltonian via the Magnus Expansion for a Three-Level System (Entropy)
Entropy, Vol. 25, Pages 236: Harmonic Phasor Estimation Method Considering Dense Interharmonic Interference (Entropy)
blog comments powered by Disqus
The latest issues of all your favorite science journals on one page


Register | Retrieve



Copyright © 2008 - 2023 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Nachrichten