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RSS FeedsPractical synthesis of isocoumarins via Rh(III)-catalyzed C–H activation/annulation cascade (Beilstein Journal of Organic Chemistry)

 
 

30 january 2023 10:47:07

 
Practical synthesis of isocoumarins via Rh(III)-catalyzed C–H activation/annulation cascade (Beilstein Journal of Organic Chemistry)
 


Abstract Herein, we report an unprecedented Rh(III)-catalyzed C–H activation/annulation cascade of readily available enaminones with iodonium ylides towards the convenient synthesis of isocoumarins. This coupling system proceeds in useful chemical yields (up to 93%) via a cascade C–H activation, Rh-carbenoid migratory insertion and acid-promoted intramolecular annulation. The success of gram-scale reaction and diverse functionalization of isocoumarins demonstrated the synthetic utility of this protocol. Beilstein J. Org. Chem. 2023, 19, 100–106. doi:10.3762/bjoc.19.10


 
52 viewsCategory: Chemistry
 
[ASAP] 1`Fluoro-1-sulfonyloxylation of Alkenes by Sterically and Electronically Tuned Hypervalent Iodine: Regression Analysis toward 1,1-Heterodifunctionalization (Organic Letters)
[ASAP] Side-Chain Grafting-Modified Sulfonated Poly(ether ether ketone) with Significantly Improved Selectivity for a Vanadium Redox Flow Battery (Industrial & Engineering Chemistry Research)
 
 
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