MyJournals Home  

RSS FeedsIJMS, Vol. 24, Pages 2693: Unlocking Kuhn Verdazyls: New Synthetic Approach and Useful Mechanistic Insights (International Journal of Molecular Sciences)

 
 

31 january 2023 10:59:36

 
IJMS, Vol. 24, Pages 2693: Unlocking Kuhn Verdazyls: New Synthetic Approach and Useful Mechanistic Insights (International Journal of Molecular Sciences)
 


An optimized synthetic protocol toward the assembly of Kuhn verdazyls based on an azo coupling of arenediazonium salts with readily available hydrazones followed by the base-mediated cyclization of in situ formed formazans with formalin was developed. The scope and limitations of the presented method were revealed. Some new mechanistic insights on the formation of Kuhn verdazyls were also conducted. It was found that in contradiction with previously assumed hypotheses, the synthesis of verdazyls was accomplished via an intermediate formation of verdazylium cations which were in situ reduced to leucoverdazyls. The latter underwent deprotonation under basic conditions to generate corresponding anions which coproportionate with verdazylium cations to furnish the formation of Kuhn verdazyls. The spectroscopic and electrochemical behavior of the synthesized verdazyls was also studied. Overall, our results may serve as a reliable basis for further investigation in the chemistry and applications of verdazyls.


 
79 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 24, Pages 2683: Pyruvate Kinase M2: A New Biomarker for the Early Detection of Diabetes-Induced Nephropathy (International Journal of Molecular Sciences)
IJMS, Vol. 24, Pages 2694: Enhanced Antibacterial Activity of Substituted Derivatives of NCR169C Peptide (International Journal of Molecular Sciences)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Molecular Biology


Copyright © 2008 - 2024 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Nachrichten