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RSS FeedsIJMS, Vol. 24, Pages 2728: Mechanobiology of the Human Intervertebral Disc: Systematic Review of the Literature and Future Perspectives (International Journal of Molecular Sciences)

 
 

1 february 2023 07:19:21

 
IJMS, Vol. 24, Pages 2728: Mechanobiology of the Human Intervertebral Disc: Systematic Review of the Literature and Future Perspectives (International Journal of Molecular Sciences)
 


Low back pain is an extremely common condition with severe consequences. Among its potential specific causes, degenerative disc disease (DDD) is one of the most frequently observed. Mechanobiology is an emerging science studying the interplay between mechanical stimuli and the biological behavior of cells and tissues. The aim of the presented study is to review, with a systematic approach, the existing literature regarding the mechanobiology of the human intervertebral disc (IVD), define the main pathways involved in DDD and identify novel potential therapeutic targets. The review was carried out in accordance with the Preferential Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Studies were included if they described biological responses of human IVD cells under mechanical stimulation or alterations of mechanical properties of the IVD determined by different gene expression. Fifteen studies were included and showed promising results confirming the mechanobiology of the human IVD as a key element in DDD. The technical advances of the last decade have allowed us to increase our understanding of this topic, enabling us to identify possible therapeutic targets to treat and to prevent DDD. Further research and technological innovations will shed light on the interactions between the mechanics and biology of the human IVD.


 
72 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 24, Pages 2727: Retinal Tissue Shows Glial Changes in a Dravet Syndrome Knock-in Mouse Model (International Journal of Molecular Sciences)
IJMS, Vol. 24, Pages 2729: Vascular Endothelial Growth Factor as Molecular Target for Bronchopulmonary Dysplasia Prevention in Very Low Birth Weight Infants (International Journal of Molecular Sciences)
 
 
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