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RSS FeedsAlgorithms, Vol. 16, Pages 168: Network Modeling of Murine Lymphatic System (Algorithms)

 
 

20 march 2023 10:58:58

 
Algorithms, Vol. 16, Pages 168: Network Modeling of Murine Lymphatic System (Algorithms)
 


Animal models of diseases, particularly mice, are considered to be the cornerstone for translational research in immunology. The aim of the present study is to model the geometry and analyze the network structure of the murine lymphatic system (LS). The algorithm for building the graph model of the LS makes use of anatomical data. To identify the edge directions of the graph model, a mass balance approach to lymph dynamics based on the Hagen–Poiseuille equation is applied. It is the first study in which a geometric model of the murine LS has been developed and characterized in terms of its structural organization and the lymph transfer function. Our study meets the demand for quantitative mechanistic approaches in the growing field of immunoengineering to utilize or exploit the lymphatic system for immunotherapy.


 
87 viewsCategory: Informatics
 
Algorithms, Vol. 16, Pages 167: Literature Review on Hybrid Evolutionary Approaches for Feature Selection (Algorithms)
Algorithms, Vol. 16, Pages 169: Pushing the Limits of Clingo’s Incremental Grounding and Solving Capabilities in Practical Applications (Algorithms)
 
 
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