Serum BAFF and APRIL levels in patients with IgG4-related disease and their clinical significance (Arthritis Research & Therapy)

IntroductionB cell-activating factor of the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) play a crucial role in B cell development, survival, and antibody production. Here we analyzed the serum levels of BAFF and APRIL and their respective clinical associations in patients with an immunoglobulin (Ig)G4-related disease (IgG4RD). Methods: We measured serum levels of BAFF and APRIL in patients with IgG4-RD, primary Sjogren`s syndrome (pSS), and healthy individuals. Serum BAFF and APRIL levels in IgG4-RD were assessed for correlations with serological parameters, including Ig, particularly IgG4, and the number of affected organs. Serum BAFF and APRIL levels in IgG4-RD were monitored during glucocorticoid (GC) therapy. Results: Serum BAFF and APRIL levels in patients with IgG4-RD were significantly higher (P