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RSS FeedsPrognostic significance of MyD88 expression by human epithelial ovarian carcinoma cells (Journal of Translational Medicine)


25 april 2012 17:31:45

Prognostic significance of MyD88 expression by human epithelial ovarian carcinoma cells (Journal of Translational Medicine)

Background: MyD88 is an adaptor protein for TLR-4 signaling known to mediate paclitaxel resistance inepithelial ovarian carcinoma (EOC). This study examined the clinical significance of MyD88expression in EOC. Methods: MyD88 and TLR-4 expression were examined by immunocytochemistry in 109 specimens ofovarian tissues, comprising EOC (N = 83), borderline tumors (N = 9), benign cysts (N = 9) andnormal ovarian tissue (N = 8), and clinical data collected by a retrospective chart review. Thecorrelations between MyD88 expression and clinicopathological factors and outcomes wereanalyzed. Results: TLR-4 expression was detected frequently in all the ovarian tissues. Distinct MyD88expression was showed in EOC (64 of 83, 77.1 %), in borderline tumors (5 of 9, 55.6 %) andin benign cysts (3 of 9, 33.3 %), and normal ovarian tissue showed no MyD88 expression.Positive MyD88 expression significantly correlated with shorter disease-free and overallsurvival for EOC (P < 0.0001 and P = 0.0031), and high MyD88 expression was significantlycorrelated with tumor metastasis (P = 0.0012) for EOC. Univariate and multivariate analysesrevealed that MyD88 expression was an independent prognostic factor for disease-freesurvival and overall survival for EOC. Conclusion: Our data indicate that MyD88 expression is a significantly poor prognostic factor for EOC. Abetter understanding of the role of MyD88 expression in disease progression and outcomemay be helpful for development of novel chemotherapies for patients with EOC. Digg Facebook Google StumbleUpon Twitter
201 viewsCategory: Medicine
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