MyJournals Home  

RSS FeedsEffects of phlebotomy-induced reduction of body iron stores on metabolic syndrome: Results from a randomized clinical trial (BMC Medicine)


30 may 2012 12:18:53

Effects of phlebotomy-induced reduction of body iron stores on metabolic syndrome: Results from a randomized clinical trial (BMC Medicine)

Background: Metabolic syndrome (METS) is an increasingly prevalent but poorly understood clinical entity characterized by insulin resistance, glucose intolerance, dyslipidemia, hypertension and obesity. Increased oxidative stress catalyzed by accumulation of iron in excess of physiologic requirements has been implicated in the pathogenesis of METS but cause-and-effect relationships remain uncertain. The hypothesis that phlebotomy-induced reduction of body iron stores would alter clinical manifestations of METS was tested by a randomized trial. Methods: In a randomized-controlled single-blinded clinical trial 64 patients with METS were randomly assigned to iron reduction by phlebotomy (n=33) or to a waiting-list control group (n=31). Iron reduction patients had 300ml of blood removed at item and between 250-500ml removed after 4 weeks depending on item ferritin levels. Primary outcomes were change of systolic blood pressure and of insulin sensitivity as measured by HOMA-Index after 6 weeks. Secondary outcomes included HbA1c, plasma-glucose, blood lipids and heart rate. Results: Systolic blood pressure decreased from 148.5+/-12.3 mmHg to 130.5+/-11.8 mm Hg in the phlebotomy group and from 144.7+/-14.4 mmHg to 143.8+/-11.9 mmHg in the control group (difference -16.6 mmHg;95%-CI:-20.7;-12.5;p Digg Facebook Google StumbleUpon Twitter
184 viewsCategory: Medicine
A cross-sectional study assessing the self-reported weight loss strategies used by adult Australian general practice patients (BMC Family Practice)
Defining cut-off values for disease activity states and improvement scores for patient-reported outcomes: the example of the Rheumatoid Arthritis Impact of Disease (RAID). (Arthritis Research & Therapy)

The articles that are most similar to this article

13.39 30-05-2012 11:48:34 Back to past leeches: repeated phlebotomies and cardiovascular risk (BMC Medicine)
8.39 30-05-2012 20:51:27 Cognitive behavioural therapy versus multidisciplinary rehabilitation treatme... (Trials)
6.98 30-05-2012 20:36:48 Design and current status of CONTINT: continuous versus interrupted abdomina... (Trials)
6.59 31-05-2012 03:07:10 Small incision lenticule extraction (SMILE) versus laser in-situ keratomileu... (Trials)
6.12 29-05-2012 16:53:59 The effects of exercise during pregnancy on the newborn`s brain: study protoc... (Trials)
5.76 30-05-2012 19:22:53 Computational challenges and human factors influencing the design and use of... (BMC Medical Informatics and Decision Making)
5.76 30-05-2012 10:46:02 Short bowel syndrome presenting with re-feeding syndrome in a Han Chinese pat... (Journal of Medical Case Reports)
4.46 29-05-2012 13:07:25 Changes in body weight and food choice in those attempting smoking cessation:... (BMC Public Health)
4.38 30-05-2012 21:37:53 Intranasal fentanyl versus intravenous morphine in the emergency department ... (Trials)
4.07 30-05-2012 14:53:09 Treatment with the arginase inhibitor N omega-hydroxy-nor-L-arginine restores... (Arthritis Research & Therapy)
3.32 29-05-2012 13:37:25 Rhodiola rosea for physical and mental fatigue: a systematic review (BMC Complementary and Alternative Medicine)
3.01 30-05-2012 12:36:04 Isolated trigeminal nerve palsy with motor involvement as a presenting manife... (International Archives of Medicine)
2.98 30-05-2012 18:48:01 Clinical validation of a new thermodilution system for the assessment of card... (Critical Care)
2.82 29-05-2012 12:22:53 Diet, occupational exposure and early asthma incidence among bakers, pastry m... (BMC Public Health)
2.51 30-05-2012 12:49:45 Sesamin Stimulates Osteoblast Differentiation Through p38 and ERK1/2 MAPK Sig... (BMC Complementary and Alternative Medicine)
2.45 30-05-2012 18:05:26 Evaluating joint-space narrowing and cartilage loss in rheumatoid arthritis u... (Arthritis Research & Therapy)
1.95 29-05-2012 17:22:14 Statistical challenges in the development and evaluation of marker-based clin... (BMC Medicine)
1.94 29-05-2012 14:47:59 Biomechanics of the press-fit phenomenon in dental implantology: an image-bas... (Head & Face Medicine)
1.76 29-05-2012 13:37:16 Porous high-density polyethylene in facial reconstruction and revision rhinop... (Head & Face Medicine)
1.58 31-05-2012 11:31:40 The relationship between hand osteoarthritis and serum leptin concentration i... (Arthritis Research & Therapy)
blog comments powered by Disqus
The latest issues of all your favorite science journals on one page


Register | Retrieve



Use these buttons to bookmark us: Digg Facebook Google StumbleUpon Twitter

Valid HTML 4.01 Transitional
Copyright © 2008 - 2016 Indigonet Services B.V.. Contact: Tim Hulsen
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Travel Photos Nachrichten Indigonet Finances Leer Mandarijn
Indigonet Services BV is not responsible for any incorrect or outdated information on this site.
If, however, you would like to see an article removed, you can send us an e-mail quoting the article number.