MyJournals Home  

RSS FeedsEffects of phlebotomy-induced reduction of body iron stores on metabolic syndrome: Results from a randomized clinical trial (BMC Medicine)

 
 

30 may 2012 12:18:53

 
Effects of phlebotomy-induced reduction of body iron stores on metabolic syndrome: Results from a randomized clinical trial (BMC Medicine)
 




Background: Metabolic syndrome (METS) is an increasingly prevalent but poorly understood clinical entity characterized by insulin resistance, glucose intolerance, dyslipidemia, hypertension and obesity. Increased oxidative stress catalyzed by accumulation of iron in excess of physiologic requirements has been implicated in the pathogenesis of METS but cause-and-effect relationships remain uncertain. The hypothesis that phlebotomy-induced reduction of body iron stores would alter clinical manifestations of METS was tested by a randomized trial. Methods: In a randomized-controlled single-blinded clinical trial 64 patients with METS were randomly assigned to iron reduction by phlebotomy (n=33) or to a waiting-list control group (n=31). Iron reduction patients had 300ml of blood removed at item and between 250-500ml removed after 4 weeks depending on item ferritin levels. Primary outcomes were change of systolic blood pressure and of insulin sensitivity as measured by HOMA-Index after 6 weeks. Secondary outcomes included HbA1c, plasma-glucose, blood lipids and heart rate. Results: Systolic blood pressure decreased from 148.5+/-12.3 mmHg to 130.5+/-11.8 mm Hg in the phlebotomy group and from 144.7+/-14.4 mmHg to 143.8+/-11.9 mmHg in the control group (difference -16.6 mmHg;95%-CI:-20.7;-12.5;p


Del.icio.us Digg Facebook Google StumbleUpon Twitter
 
185 viewsCategory: Medicine
 
A cross-sectional study assessing the self-reported weight loss strategies used by adult Australian general practice patients (BMC Family Practice)
Defining cut-off values for disease activity states and improvement scores for patient-reported outcomes: the example of the Rheumatoid Arthritis Impact of Disease (RAID). (Arthritis Research & Therapy)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Medicine

Use these buttons to bookmark us:
Del.icio.us Digg Facebook Google StumbleUpon Twitter


Valid HTML 4.01 Transitional
Copyright © 2008 - 2016 Indigonet Services B.V.. Contact: Tim Hulsen
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Travel Photos Nachrichten Indigonet Finances Leer Mandarijn
Indigonet Services BV is not responsible for any incorrect or outdated information on this site.
If, however, you would like to see an article removed, you can send us an e-mail quoting the article number.