Connective tissue diseases: Depleting plasmacytoid dendritic cells: a new therapeutic approach in SLE? (Nature Clinical Practice Rheumatology)

Plasmacytoid dendritic cells (pDCs), a distinct subtype of dendritic cells that specialize in the secretion of high levels of IFN-? and IFN-? in response to viral nucleic acids, have frequently been implicated in the pathogenesis of systemic lupus erythematosus (SLE). To date, however, the supporting