Autoinflammation: NLRC4 mutation causes rare autoinflammatory disease (Nature Clinical Practice Rheumatology)

Two papers, from different groups and published back-to-back in the journal Nature Genetics, report on the independent discovery of distinct gain-of-function NLRC4 mutations that cause an autoinflammatory syndrome pathologically distinct from NLRP3 cryopyrinopathies.Scott Canna, first author of one of the papers,