Immunology: IgG1 protects against renal disease induced by pathogenic antibody isotypes (Nature Clinical Practice Nephrology)

Immunoglobulin isotypes that poorly activate effector mechanisms that protect the host against pathogens can induce anti-inflammatory effects and protect against immune-complex-dependent renal disease, according to new research. `Our findings indicate that less pathogenic antibody isotypes, such as mouse IgG1 and probably human IgG4, can protect