Glomerular disease: Thrombospondin type-1 domain-containing 7A--a new player in membranous nephropathy (Nature Clinical Practice Nephrology)

In 2009, the podocyte receptor phospholipase A2 receptor 1 (PLA2R1) was identified as the first major autoantigen involved in the pathogenesis of adult idiopathic membranous nephropathy (iMN). Subsequent studies confirmed circulating autoantibodies to PLA2R1 in approximately 70% of affected patients; however, the cause of disease